Osteoporosis research paper pdf

Bortezomib prevents ovariectomy-induced osteoporosis in mice by inhibiting osteoclast differentiation
AbstractBone homeostasis is achieved through coordinated activities of bone-forming osteoblasts and bone-resorbing osteoclasts. When the balance is skewed in favor of osteoclasts due to hormonal or inflammatory issues, pathologic bone loss occurs leading to conditions such as osteoporosis, rheumatoid arthritis, and periodontitis. Bortezomib is the first in-class of proteasome inhibitors used as an anti-myeloma agent. In the present study, we show that bortezomib directly inhibited the receptor activator of nuclear factor κB ligand (RANKL)—dependent osteoclast differentiation of mouse bone marrow macrophages. Bo...
Source: Journal of Bone and Mineral Metabolism - October 12, 2017 Category: Orthopaedics Source Type: research

Osteoporosis research paper pdf

osteoporosis research paper pdf


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